Within one week of deleting leptin receptors from POMC neurons in adult mice, he observed impairment in hepatic glucose production, independent of changes in energy balance.
Onderstepoort Veterinary Journal, 79 1 : 5. Spatial overlap between sympatric wild and domestic herbivores links to resource gradients. Conserving Africa's wildlife and wildlands through the COVID crisis and beyond. Proc Roy Soc B, :
Caron Alexandre 05/08/75 French Nationality, Male, Married, 2 children Disease ecologist at wildlife/domestic interfaces Full-time Researcher Cirad, Research Unit AGIRs, Department "Environment and Societies" == D.V.M. MSc MSc PhD == Veterinary school of Cirad / Uni. of Maisons- Alfort Montpellier II M.R.I. / Uni. of Pretoria Cirad / Uni.
- International Conference of the Association of Institutions of Tropical Veterinary Medicine.
- J Wildl Dis SS
- The Condor, doi:
- French and English fluent, Spanish spoken level A2 , Portuguese level A1 Common use of various Informatics and Statistic Software 4 Summerfield close, Highland, Harare, Zimbabwe alexandre.
Lot 103: Alexandre Auguste Caron (1857-1932), a carved ivory figure 'Jeune fille se. Auction Date: Nov 03, 2020 Estimate: £200 - £300 Description: Alexandre Auguste Caron (1857-1932), a carved ivory figure 'Jeune fille se coiffant' c.1910, signed on the ivory base A Caron Carved as a classical maiden, her dress exposing one breast, she stands holding her hands to adjust her hair, on ...
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Alexandre Caron. Lycée Adolphe Chérioux. Habite à Saintes. Connectez-vous ou inscrivez-vous sur Facebook pour communiquer avec vos amis, votre famille et vos connaissances.
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Adipose tissue Adrenergic Receptors Autonomic nervous system Chemogenetics Diabetes Glucose Metabolism Hypothalamus Leptin Liver Non-shivering thermogenesis Obesity Alexandre Caron Sketch Alexandre Caron obtained his PhD in Physiology-Endocrinology from Laval University in His graduate work with Drs. Denis Richard and Mathieu Laplante focused on understanding the role of DEP domain-containing mTOR-interacting protein DEPTOR in energy, glucose and lipid homeostasis.
His graduate research also involved the study of the molecular mechanisms regulating non-shivering thermogenesis in brown adipose tissue. After graduating, Dr. Alexandre Caron joined the laboratory of Dr. Joel Elmquist Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center first as a Diabetes Canada Postdoctoral Fellow and then as a Banting Postdoctoral Fellow.
His postdoctoral work aimed at understanding how the central leptin-melanocortin system controls adipose metabolic and endocrine functions. He also developed an arsenal of genetic models allowing the manipulation of key autonomic receptors. InDr. Under the mentorship of the chemist Dr. Shawn Burgess Center for Human Nutrition, University of Texas Southwestern Medical Centerhe started combining mouse genetics, chemogenetics and Alexandre Caron isotope approaches.
In Marchhe was appointed a position of Assistant Professor in Pharmacy at Laval University Alexandre Caron established his laboratory at the Quebec Heart and Alexandre Caron Institute. Identification and characterization of DEPTOR in the central nervous system and investigation of its role in energy and glucose metabolism. During his PhD, Dr. Caron became interested in understanding how the hypothalamus controls energy balance and glucose homeostasis.
His Intellectual Capital aimed at elucidating the metabolic role of a novel endogenous inhibitor of mTOR signaling name DEPTOR. He was the first to Alexandre Caron the distribution of DEPTOR in the rodent central nervous system, shedding the lights on the potential implication of. DEPTOR in the autonomic Alexandre Caron of energy and glucose homeostasis. Using Dating Seiten Ab 16 Kostenlos conditional transgenic mouse lines, he generated different Gowther Demon allowing systemic, hypothalamic, neuronal and liver-specific overexpression and deletion of DEPTOR.
Caron found that hypothalamic overexpression of DEPTOR protects against diet-induced obesity and insulin resistance by improving neuronal insulin sensitivity. In order to determine the role of DEPTOR in discreet hypothalamic neurons, he thereafter showed that its overexpression in pro-opiomelanocortin POMC neurons affects glucose and lipid homeostasis through a fascinating brain-liver connection.
He also discovered that loss of DEPTOR cell-autonomously increases oxidative metabolism in hepatocytes, resulting in a reduction in circulating glucose and hepatic glycogen content upon fasting. Revisiting the Central Leptin-Melanocortin system using modern genetic tools. A prevalent dogma in the field is that leptin signaling in pro-opiomelanocortin POMC is key in regulating energy balance and glucose homeostasis.
This idea is based on global knock-out models, which were shown to Xxxmilf to developmental compensation and off-targets.
Caron used a tamoxifen-inducible POMC-CreERT2 transgenic mouse model to generate mice in which the leptin receptor expression is spatiotemporally-controlled in a neuron-specific fashion. Within one week of deleting leptin receptors from POMC neurons in adult mice, he observed impairment in hepatic glucose production, independent of changes in energy Grille Aggir. This was one of the first study Alexandre Caron clearly dissociate the effects of the leptin-melanocortin system on glucose homeostasis versus changes in energy balance.
Harnessing the power of chemogenetics to develop a Alexandre Caron of transgenic models allowing the specific and spatiotemporal stimulation of GPCR signaling in Alexandre Caron organs. Chemical genetics, also known as chemogenetics, is an approach use to genetically engineer receptors that Busty Asian Tube. This approach has been used to create modified G-couple protein receptors GPCRsAlexandre Caron Designer Receptors Exclusively Activated by Designer Drugs DREADDs.
Originally developed to control neuronal activity, DREADDs are emerging as key tools for selective pharmacological control of GPCR signaling in any Festival Blowjob type or organ. Recently, Dr. Caron reported the generation of a novel chemogenetic approach allowing acute stimulation of GsPCR and GiPCR Alexandre Caron in adipocytes in vivo and ex vivo. This innovative model revealed important, previously unappreciated complex interactions of GPCR signaling in adipose tissue and demonstrated the usefulness of chemogenetic technology to better understand cell and tissue function.
His laboratory studies the pathophysiological mechanisms that alter brain-organs communication in metabolic diseases and aims to identify new molecular and pharmacological targets in the brain and peripheral organs to improve energy and glucose metabolism.
His work focusses on defining neuronal circuits involved in the control of hepatic glucose production Diosa Blonde adipose lipid handling, and investigating autonomic receptor signaling pathways in metabolic organs. His objective is to make the fields of obesity and diabetes move forward and to directly impact on health research and clinical practices, by uncovering molecular and pharmacological targets for the treatment of metabolic disorders.
First Name. Last Name. Email address:. Dr Alexandre Caron Faculty of Alexandre Caron, Laval University. Quebec Heart and Lung Institute chemin Ste-Foy, room Y Research keywords Adipose tissue Adrenergic Receptors Autonomic nervous system Chemogenetics Diabetes Glucose Metabolism Hypothalamus Leptin Liver Non-shivering thermogenesis Obesity.
Biographical Sketch. Alexandre Caron obtained his PhD in Physiology-Endocrinology from Laval University in Selected Scientific Contributions. He was the first to characterize the distribution of DEPTOR in the rodent central nervous system, shedding the lights on the potential implication of DEPTOR in the autonomic regulation of energy and glucose homeostasis.
Journal of Comparative Neurology Alexandre Caron Molecular metabolism 5. Am J of Physiology-Regulatory Molecular metabolism 6.
Physiological reviews Elife 7 : e Chemical genetics, also known as chemogenetics, is an approach use to genetically engineer receptors Alexandre Caron interact with previously unrecognized small molecule chemical actuators. Molecular metabolism 27 : Research Alexandre Caron. Subscribe to our Newsletter First Name Last Name Email address: Leave this field empty if you're human:.
Publication Date: Publication Name: New Frontiers of Molecular Epidemiology of Infectious Diseases. Publication Date: Publication Name: Onderstepoort Journal of Veterinary Research. Grosbois , Josphine Mundava , Alexandre Caron , and Tim Dodman. Publication Date: Publication Name: PLoS ONE. Publication Date: Publication Name: BMC Evolutionary Biology. Publication Date: Publication Name: Veterinary Research.
Publication Date: Publication Name: Tropical Animal Health and Production. Publication Date: Publication Name: Transboundary and Emerging Diseases. Veterinary Sciences. Publication Date: Publication Name: Parasitology. Publication Date: Publication Name: Ostrich. Publication Date: Publication Name: Infection, Genetics and Evolution. Grosbois , and E.
Publication Date: Publication Name: Emerging Infectious Diseases. Publication Date: Publication Name: Ecological Applications. Publication Date: Publication Name: EcoHealth. Miguel , Alexandre Caron , Michel de Garine-Wichatitsky , B. Mukamuri , and Eric Garine. Publication Date: Publication Name: Comparative Immunology, Microbiology and Infectious Diseases. Etter , and Ferran Jori. Publication Date: Wildlife Diseases and Wildlife. Fran Grace Helen Filthy 50 Sprint m -- Run 5k Proud Partner.
Proud Sponsor. Chapter Challenging the conceptual framework ofmaintenance hosts for inlfuenza A viruses in wild birds. Journal of Applied Ecology, 54 3 : Using network analysis to identify key-rodent hosts as potential sources of emerging zoonotic diseases in the human-dominated landscapes of Southeast Asia.
Cahiers de l'Agriculture, 25 5 : Ecological and epidemiological roles of camels: lessons from existing and emerging viral infections. Empress - Animal Health, Role of breeding phenology and aggregation of waterfowl on avian influenza dynamics in southern Africa. Ibis, The ecology of infectious disease transmission in multi-host systems in African socio-ecosystems. African Journal of Ecology, 54 4 : One Health and EcoHealth: same wine in different bottles?
From field activities in low-income countries to revised concepts. Infection, Ecology and Epidemiology, 6: Transfrontier Conservation Areas, Buffalo Movements and Animal Diseases.
Emerging Infectious Diseases, 22 2 : Testing epidemiological functional groups as predictors of avian haemosporidia patterns in southern Africa. Ecosphere, 7 4 : e Transboundary and Emerging Diseases, 63 1 : e Applied and Environmental Microbiology, 82 5 : Spatial overlap between sympatric wild and domestic herbivores links to resource gradients. Remote Sensing Applications: Society and Environment, 2: Bridge host, a missing link in disease ecology in multi-host systems.
Veterinary Research, A social-ecological approach to landscape epidemiology: geographic variation and avian influenza. Landscape Ecology, 30 6 : Wild and Domestic; Human and Animal: a sanitary surveillance blurring boundaries French. Revue d'Anthropologie des Connaissances, 9 2 : Avian Influenza in the world: update on 31st Janaury French.
Empres-animal health 44 2 : Preventive Veterinary Medicine, Genetic structure of fragmented southern populations of African Cape buffalo Syncerus caffer caffer. BMC Evolutionary Biology, Empirical analysis suggests continuous and homogeneous circulaiton of Newcastle Disease virus in a wide range of wild birds species in Africa.
Characterising African tick communities at a wild-domestic interface using repeated sampling protocols and models. Acta Tropica, Livestock and buffalo Syncerus caffer interfaces in Africa: ecology of disease transmission and implications for conservation and development. In: Ecology, Evollution and Behaviour of wild Cattle. Implications for Conservation. Melletti, M.
Cambridge University Press, Chapter Evaluating the potential for the environmentally sustainable control of foot and mouth disease in Sub-Saharan Africa. Ecohealth, 10 3 : Grosbois, A. Caron , D. Cornelis, T. Boulinier, H. Fritz, C. Foggin, P. Makaya, P. Tshabalala, and M. Ecosphere, 4 4 : art Caron , R. Kock, R. Tschopp, M. Munyeme, M.
Hofmeyr, and A. Epidemiology and Infections, Pan-African Genetic Structure in the African Buffalo Syncerus caffer : Investigating Subspecies Divergence. PLoS ONE, 8:e Host associations, biogeography, and a first phylogeny of avian malaria in southern African waterfowl.
Alexandre Caron Profiles - Facebook
Alexandre Caron. 943 followers. Colegio Estadual Conselheiro Quielse Crisostomo da Silva Lives in Bocaiúva do Sul.
Alexandre Caron, CIRAD, Environment and Society Department, Faculty Studies Drug Resistance, Surveillance Epidemiology, and Clinical Epidemiology. Lot Alexandre Auguste Caron (), a carved ivory figure 'Jeune fille se. Auction Date: Nov 03, Estimate: £ - £ Description: Alexandre Auguste Caron (), a carved ivory figure 'Jeune fille se coiffant' c, signed on the ivory base A Caron Carved as a classical maiden, her dress exposing one breast, she stands holding her hands to adjust her hair, on. Alexandre Caron | Moçambique | Researcher na CIRAD | I am hosted at Eduardo Mondlane University in Mozambique since after 9 years in Zimbabwe. | + conexões | Ver perfil completo de Alexandre e conectar no LinkedInTitle: Disease ecology / Sustainability .
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